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Description
Link to the FDA's statement in comments

Healthcare thematics & trends The 2020 Digital Health 150 list is representative of many of the key thematics and trends weve observed across healthcare in the past year
There have also been signals consistent with the broader GLP-1 receptor agonist class relating to a potential increased risk of gallbladder-related conditions, such as cholelithiasis (gallstones), particularly in the context of rapid weight loss
FDA labels note that dehydration from gastrointestinal adverse effects can contribute to acute kidney injury in some cases

Asparagine, especially when followed by glycine in the sequence (Asn-Gly), is a "hot spot" for deamidation

Thats where GLP-1 medicines come in
