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Since December 2025, the Wegovy pill, an oral option, is also available for patients who prefer not to undergo injections

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Some patients may also experience changes in blood glucose regulation that could affect temperature perception

Importantly, using recombinant GLP-1 agonists improved the study by isolating the specific effects of synthetic GLP-1, removing confounding effects linked to the clinical formulations of the peptide

Researchers using DEXA scans or waist circumference measurements often see disproportionate reductions in trunk fat compared to peripheral fat during this phase