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younger) adults, largely explained by underlying CVD [81]

Clinical guidance recommends a lower-calorie plan, roughly 1,200 to 1,500 calories daily for most women and 1,500 to 1,800 for most men, combined with about 1 to 1.2 grams of protein per kilogram of body weight to protect muscle

In cells exposed to HG, TIR failed to affect AGBL4 mRNA and protein levels (Fig

Together they aim to cover fat metabolism, systemic signaling, and direct tissue repair

Subsequently, 60 studies were excluded due to the absence of alcohol-related outcomes, lack of GLP-1RA exposure, or unsuitable study design

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