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Description
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for diabetes and obesity, exhibit pleiotropic effectsincluding anti-inflammatory, ...

Carmot Therapeutics has revealed preliminary data from the single ascending dose (SAD) portion of its ongoing Phase 1 clinical trial for CT-996, an oral small molecule GLP-1 receptor agonist (RA) currently being evaluated in a first-in-human clinical trial in participants with obesity or overweight.CT-996 is a once-daily oral, small molecule GLP-1 receptor agonist being developed for the treatment of obesity and type 2 diabetes (T2D)

Helps control hunger, cravings, and portion sizes

Primary care physicians can prescribe GLP-1 receptor agonists for weight management in eligible patients
We used version 2 of the Cochrane risk-of-bias tool for randomised trials to assess risk of bias for the primary outcome

Wegovy requires patients to be 18 years or older, but age alone doesn't determine readiness for GLP-1 therapy
