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Hence, GLP-1s as a class were not considered to modify the natural history of the disease as they were not anti-fibrotics. In 2024, this perception was challenged as the dual agonists tirzepatide (Mounjaro/Zepbound, Eli Lilly

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A common pattern is dropping retatrutide from 12 mg to 8 mg/week once cagrilintide is at 1.7-2.4 mg/week

The fatty acid acylation of cagrilintide enables albumin binding in circulation, reducing renal clearance and extending the elimination half-life to support once-weekly dosing