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Briefly, Nb35 target gene was transformed in the bacterium and amplified in TB culture medium with 100 g/mL ampicillin, 2 mM MgCl 2 , 0.1% (w/v) glucose at 37 C, 180 rpm

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To improve transparency, an adapted PRISMA-style flow diagram documenting identification, screening, eligibility assessment, de-duplication, and selection of the RCT evidence base and the proof-of-concept Bayesian subset is provided in the Supplementary Appendix Figure 1, together with details of the search strategy, screening process, and data extraction