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Description
About SELECT SELECT (Semaglutide Effects on Heart Disease and Stroke in Patients with Overweight or Obesity) was a randomised, double-blind, parallel-group, placebo-controlled trial designed to evaluate the efficacy of semaglutide 2.4 mg versus placebo as an adjunct to standard of care for reducing the risk of MACE in people with established CVD with overweight or obesity with no prior history of diabetes

For a service that charges for provider-guided care, this is a significant concern
This is a meaningful advantage over oral B12 supplements that must navigate the same slowed, acid-depleted environment that semaglutide creates
Newer data suggest a significant reduction in cardiovascular events with GLP-1 agonist therapy in patients who are overweight or obese and have a prior history of heart disease

39 , e3673 (2023)

Stopping and restarting creates repeated rebound cycles that are less effective than continuous therapy
