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For the nasal spray formulation, approval requires evidence from phase 3 registration trials, which haven't yet begun according to public registries

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doi: 10.1152/ajpregu.00460.2015 86 ChanSWLinGYewDTYeungCKRuddJA

Dr Ducharme and her staff are very thorough, explain what they are doing and very pleasant to work with

Injectable Solution : Methylene blue is used as an injectable solution as a medical treatment to treat methemoglobinemia (a blood disorder), as an antidote to cyanide or carbon monoxide poisoning and as a surgical marker to dye tissues during surgery