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Description
2025 doi: 10.1136/heartjnl-2024-324847
Receptors implicated in FFA regulation of GLP-1 secretion include GPR120 (FFAR4) and GPR40 (FFAR1), both of which are activated by long-chain fatty acids
The findings are based on analysis of data from 2.4 million participants
Concurrent use with an insulin secretagogue or insulin may raise the risk of hypoglycemia
Population-based cohort study
Tirzepatide is the first combination of entero-pancreatic hormones [dual GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) RA] that has been approved for T2D management based on the findings from the phase 3 SURPASS programme
