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Its just much harder for them to be competitive in the new era of small-molecule GLP-1 receptor agonists, oral peptide therapeutics. Secher added that there may be a physiological limit to the amount of GLP-1 that can be produced with endogenous inducers of endogenous GLP-1 release compared with pharmacological inducers

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doi:10.1016/j.jacc.2020.06.076

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