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If youre experiencing severe nausea accompanied by dehydration or an inability to eat, contact emergency health services

ClinicalTrials.gov registrations: SURMOUNT-1 NCT04184622, SURMOUNT-2 NCT04657003, SURMOUNT-3 NCT04657016, SURMOUNT-4 NCT04660643, SURMOUNT-MMO (cardiovascular outcomes) NCT05556512

The following subsections unpack how delayed gastric emptying produces nausea and other contributing factors clinicians consider when counseling patients

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Pulmonary Aspiration During General Anesthesia or Deep Sedation Inform patients that ZEPBOUND may cause their stomach to empty more slowly which may lead to complications with anesthesia or deep sedation during planned surgeries or procedures