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Additionally, the serine protease dipeptidyl peptidase 4 (DPP4) limits the bioavailability of GIP, GLP-1, and GLP-2 by cleaving the first two amino acids, rendering them inactive ( This review highlights the biology and paracrine roles of GLP-1, GIP, and GLP-2 in integrating the response to food intake with the maintenance of the structure and function of the gut as it relates to nutrient absorption

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GIP (glucose dependent insulinotropic polypeptide) receptor Enhances insulin response after meals, has direct effects on adipose tissue, and works synergistically with GLP-1 to amplify metabolic signaling

A 9.2 For most adults with type 1 diabetes, insulin analogs (or inhaled insulin) are preferred over injectable human insulins to minimize hypoglycemia risk