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Furthermore, we should be aware that when applying semaglutide in older individuals with long-term diabetes, in addition to causing gastrointestinal adverse reactions (mild or moderate nausea, vomiting, constipation, diarrhea), it may also increase the risk of diabetic retinopathy complications, which is still a matter of debate [10]

The FDA approval comes amid growing discussion about the potential uses of weight loss drugs beyond treating obesity and diabetes

Are GLP-1 drugs safe long-term

GLP-1 agonists require functioning beta cells to work

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Something that addresses the biological factors making weight loss nearly impossible - constant hunger, slowed metabolism, hormonal issues, insulin resistance