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In the ATTAIN-1 Phase 3 trial, the most frequently reported adverse events with orforglipron 36 mg versus placebo were nausea (33.7% vs 10.4%), constipation (25.4% vs 9.3%), diarrhea (23.1% vs 9.6%), and vomiting (24.0% vs 4.0%)

This means your stomach may not be emptyeven after a standard fasting period

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Data from each study was extracted independently by two authors

Available from Accessed 23 July 2024 Ethics declarations Data availability The datasets presented in this article are not readily available due to legal restrictions on sharing the dataset as regulated by the Valencia regional government by means of legal resolution by the Valencia Health Agency [2009/13312] which forbids the dissemination of data to third parties (accessible at: Upon request, authors can allow access to the databases to verify the accuracy of the analysis or the reproducibility of the study

Medaris, A