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Across the ladder, receptor engagement rises about six-fold from the starter dose to the top, and weight loss rises with it

Exenatide (Bydureon BCise, Byetta) One of the earliest GLP-1s, Exenatide is mainly focused on preventing blood sugar spikes after meals

Boehringer Ingelheim and Eli Lilly and Company

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Genetic variants in genes like FTO (rs9939609) and MC4R (rs17782313) influence baseline appetite regulation and weight-loss potential, helping clinicians tailor medication selection and dosing strategies

2 This pandemic of obesity has placed a substantial burden on healthcare systems and patients alike, sparking intense interest in the development of novel therapeutic strategies