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Craig, C

Triple agonists with GLP1, GIP and glucagon Given the efficacy and benefits of the dual GLP-1/GIP RA tirzepatide and the dual GLP-1/glucagon RA, a triple agonist targeting all three receptors (GLP-1/GIP/glucagon) may result in superior WL and glycaemic control than dual agonists

Endogenous GLP-1R signaling exerts a physiologically relevant effect on BP control, which may be attributable, in part, to its tonic actions on proximal tubule Na/H mediated sodium reabsorption, and the intrarenal renin-angiotensin II system [67]

3 In one experiment, the effect was reproduced even when autoantibodies were drawn from patients two years after their initial infection, suggesting the immune dysregulation can persist long after acute illness

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

Meta-analyses were performed on eligible studies that presented numerical data on the changes in select body composition and anthropometric parameters with GLP-1-based treatment