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Description
Very high-fat foods take more time to digest and sit in the stomach for longer
In the CNS, endogenous GLP-1 acts primarily through vagal afferent signaling, transmitting information from the gastrointestinal tract to the brainstem [123, 124]

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[DOI] [PubMed] [Google Scholar] 109.Yu X, Chen S, Funcke JB, Straub LG, Pirro V, et al

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However, fatigue is listed as a common adverse reaction in FDA labeling, particularly for Wegovy, occurring through indirect mechanisms such as caloric restriction and gastrointestinal effects rather than direct sedation