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Moreover, the results demonstrated a significant upregulation of Sqstm1 (P62, which is inversely related to autophagic activity) protein in the HFD group, suggesting that the autophagic process might be hindered [55]

Given these benefits, and indications for use that often co-occur in kidney transplant recipients, use of GLP-1RAs warrants consideration in this population

The licensing of oral semaglutide provided a step forward in type 2 diabetes management for this group, and the publication of the SOUL study in 2025 reassured us that oral semaglutide could also offer cardiovascular benefit in those at highest risk

Curr Diabetes Rev 2013;9:25-53

SUMMIT, a randomized, double-blind, placebo-controlled, phase 3 study comparing efficacy and safety of tirzepatide vs

If your symptoms persist or are unmanageable, please speak to your GP