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Alternative and non-mutually exclusive mechanisms may involve favorable effects on basal energy expenditure [57] or on the choice of less energy-rich foods consumed in free-living conditions [58], although these latter hypotheses remain to be validated in clinical studies

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The theoretical mechanism involves transdermal absorption of GLP-1 analogs or related compounds through the skin's stratum corneum into systemic circulation

A rare case of dulaglutide-associated angioedema in a male patient

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