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Safety, tolerability, pharmacokinetics and pharmacodynamics of albiglutide, a longacting GLP1receptor agonist, in Japanese subjects with type 2 diabetes mellitus

GLP-1 stands for "Glucagon-Like Peptide-1." It's a natural hormone your body makes, mainly after you eat

Toujeo is insulin glargine, a long-acting basal insulin

doi: 10.1111/dom.12651 68 HeinlaKVasarESedmanTVolkeV

The characteristic changes of GLP-1 face include 4,5 : Facial volume loss, particularly in the midface Periocular hollowing and periorbital volume depletion Dermal thinning with loss of collagen and elastin fibers Decreased skin elasticity leading to redundant skin folds Accelerated appearance of aging As a result of these facial changes, GLP-1 agonist medications can result in an older, haggard and tired looking appearance

After binding to GLP-1 receptors in pancreatic beta cells, GLP-1 RAs exert their glucose-lowering effect by stimulating glucose-dependent insulin release