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Future directions call for larger, prospective randomized controlled trials to validate efficacy, clarify mechanisms (weight loss vs

Although the first GLP-1s were approved for weight loss in 2014, usage surged in 2021

For example, in clinical trials of Wegovy (semaglutide), eructation was reported in 5.8% of patients versus 0% in the placebo group

Additionally, the self-reported nature of the study which might have imposed some bias to the results

Biomedicines 2021, 9(4)
