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3.4 Appetite regulation and weight management Similar to animal studies with deletion of the GIPR gene that exhibit protection toward obesity (53), early genome-wide association studies (GWAS) in humans have revealed the GIPR gene to be associated with BMI (103)

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The GLP-1 receptor agonist exenatide ameliorates neuroinflammation, locomotor activity, and anxiety-like behavior in mice with diet-induced obesity through the modulation of microglial M2 polarization and downregulation of SR-A4

30 Increased intestinal transit is associated with specific microbiota species, 85 and patients with bile acid diarrhea effectively treated with colesevalam had a significantly greater abundance of Fusobacterium and Ruminococcus , both of which help convert primary to secondary bile acids

Pozzilli P, Norwood P, Jdar E, et al