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These data expand the potential benefits of this molecule as an antitumor drug in vivo (Rotondi et al., 2015)

197,198 Additionally, efforts have been made to develop oral formulations with improved bioavailability ( F )

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The biological evaluation of the newly synthesized chemical agents demonstrated that molecule 63 possesses the most potent enzyme inhibition activity, with an IC 50 of 17.7 M (Figure 7)