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According to Shed's published Terms, you may be eligible for a refund or program credit if you: Fully comply with all program requirements Do not achieve at least a 10 percent reduction in baseline body weight within nine months Eligibility Requirements Per Shed's Terms: Start date must be on or after February 12, 2025 Must be your first time using the eligible medication class (GLP-1s, Bupropion plus Naltrexone, or Metformin plus Topiramate plus Naltrexone) Must complete a medical evaluation and obtain approval through Shed's network of providers Must attend all required medical follow-up visits Must complete all assigned learning modules in the Shed Member Portal Must complete monthly check-ins through the Shed Member Portal Must log weight weekly in the Shed Member Portal Must post at least once a week in the Shed Facebook Community No more than two missed virtual or text-based coaching sessions Exclusions Per Shed's Terms (Partial List): Prior use of GLP-1 medications (compounded or branded) Personal or family history of medullary thyroid cancer (MTC) or MEN 2 Type 1 diabetes Active eating disorders Severe gastrointestinal issues (gastroparesis, IBD) Significant kidney or liver disease History of pancreatitis or unmanaged gallbladder disease Pregnancy or breastfeeding Bariatric surgery within the past 12 months Use of medications that conflict with treatment Uncontrolled psychiatric conditions that affect compliance Significant hormonal changes during the program Use of other weight-loss methods not prescribed by Shed during the program Verification Process: Per Shed's Terms, weight must be self-attested weekly for the full nine-month period, each entry time-stamped and submitted consistently

Consistent with this, we demonstrate that treatment with MK-801, even at doses that do not evoke weight loss, elicits pronounced hyperthermia in DIO mice (Extended Data Fig