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Guidelines: the 2023 International PCOS Guideline positions GLP-1RAs as practical weight-loss tools for obese women with PCOS but emphasizes that they must be used within a framework of continuous, effective contraception throughout the treatment period, and should not be considered a routine intervention for weight or metabolic management during pregnancy ( Lactation: although preliminary data suggest extremely low milk transfer and no clear adverse signals in infants (163), the overall evidence remains insufficient