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Dramatic changes are unlikely initially

The phase 3 randomized withdrawal trial evaluated the long-term efficacy of tirzepatide for weight maintenance in adults with obesity or overweight

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Slow and gradual dose escalation also helps reduce gastrointestinal side effects and improve tolerability

[DOI] [PMC free article] [PubMed] [Google Scholar] 59.Shimizu I, Hirota M, Ohboshi C, Shima K