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All three compounds in the GLP-1 drug class, including Retatrutide, Tirzepatide, and Semaglutide, activate this receptor

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Godoy-Matos AF, Silva Junior WS, Valerio CM

Or it could be a disorder called trigeminal neuralgia, also known as tic douloureux

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Potential explanations include the dual receptor agonism of tirzepatide 23