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Scientists now understand that beneficial bacteria help produce compounds called short-chain fatty acids (SCFAs), including butyrate, which play major roles in insulin sensitivity, satiety signaling, gut barrier integrity, and metabolic flexibility

However, extrapolating these findings to human physiology is problematic due to significant species differences in pancreatic anatomy, GLP-1 receptor distribution, and metabolic responses

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doi: 10.1016/j.molmet.2015.09.014

This shorter window reflects the compounding advantage: medications are customized to individual needs rather than mass-manufactured

Overton, J