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However, current evidence is still inconclusive to demonstrate a direct negative effect of GLP-1 RAs on LBM loss, largely due to heterogeneity in study designs and the limited number of trials specifically evaluating this endpoint [77]

This may necessitate dose adjustments or acceptance of more variable weight loss patterns

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Moreover, peptides were considered poor drug candidatesthey required injection, were expensive to manufacture, and were generally viewed as fragile molecules unsuitable for widespread therapeutic use