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The future of GLP-1RAs in anti-inflammatory therapy looks promising, with ongoing research aiming to optimize their therapeutic use, develop patient-specific treatment paradigms, and explore novel applications

A recent analysis of FDA adverse event reporting system (FAERS) data from 2004 to 2020 revealed a notable association between GLP-1 RAs and malignant pancreatic neoplasms (proportional reporting ratio [PRR], 9.86) [52]

GLP-1 and GLP-1/GIP therapies work best when paired with proper nutrition and purposeful movement

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This multicenter, double-blind, placebo-controlled trial enrolled people with NAFLD with liver fat content at or above 10% by MRI-PDFF, a FibroScan liver stiffness measure below 10 kPa, alanine aminotransferase (ALT) at or below 75 IU/L, and no diabetes or non-insulin-dependent diabetes with A1C below 9.5%