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doi: 10.1053/j.gastro.2015.04.043

Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): A double-blind, randomised, multicentre, placebo-controlled, phase 3 trial

Even modest weight loss dramatically reduces the cytokine output from adipose tissue
Not all researchers were enamored with the data though

By enhancing feelings of fullness, slowing stomach emptying, and supporting healthy insulin response, GLP-1 medications help you eat less and better control your weight and blood sugar

BMJ 339:b2700b2700