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Semaglutide does not directly deplete NAD, but rapid weight loss and dietary restrictioncommon during early semaglutide therapymay stress cellular energy systems

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Oxyntomodulin stimulates intestinal glucose uptake in rats

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Incretin action post-oral glucose was mostly mediated by GIP, with negligible contribution from GLP-1, consistent with GLP-1's role in slowing stomach emptying