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Clinical Significance: The 2025 updates reaffirm that while HbA1c remains central, a one-number-fits-all strategy is outdated

Whether these translate into meaningful extensions of healthspanor ultimately lifespanremains one of the biggest unanswered questions in medicine

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The news: Connecticut plans to ask the federal government to allow it to contract for generic GLP-1 drugs for state employees and Medicaid patients

Semaglutide is often optimized to maximize weight loss, yet it remains unclear whether long-term cardiovascular benefit is more closely associated with achieved weight reduction or therapeutic exposure
