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Efinopegdutide is another GLP-1R and GCGR dual agonist currently under clinical investigation, which is being explored in studies for patients with obesity, type 2 diabetes (T2D), and metabolically associated fatty liver disease/multiple acyl-CoA dehydrogenase deficiency syndrome (MASLD/MASH)

This blockade prevents normal drug metabolism, causing unexpected increases in blood levels and prolonged medication exposure

Avoid high-fat meals, large portions, and foods known to cause GI distress independently

But in this space, red flags can be subtler

Ananthanarayanan M, Balasubramanian N, Makishima M, et al

Carvalho, B