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Drug Effect Weight loss itself can rob bone density through four pathways: Mechanical unloading less body weight and fewer impact forces Hormonal shifts leptin and estrogen fall as fat shrinks Nutrient shortfalls calorie cuts often mean less calcium and protein Muscle loss weaker muscles increase fall risk and provide less bone-stimulating tension Banner Health notes that even dropping 10 lb in three months can measurably lower BMD in older adults

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Nevertheless, Graham suggested that newer market entrants could learn important lessons from the first round of obesity treatments

If youve been following developments in weight loss medications, youve probably heard about Retatrutide