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Conflict of interest BG has served as a consultant for AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Merck (MSD) and Novartis as manufacturers of DPP-4 inhibitors and has received honoraria from these companies for lectures

A 48-week Phase 2 trial reported in The Lancet in 2025 showed mean weight reduction ranging from approximately 9% at the lowest dose to 20% at the highest dose, compared with 0.4% on placebo

Leading generic manufacturers and API suppliers include: Mylan, Teva, Sandoz, Lupin, Dr

This research led to the development of two blockbuster weight-loss drugs: Wegovy by Novo Nordisk and Zepbound by Eli Lilly, now prescribed to millions as obesity affects 1 in 8 people globally

Aetna typically requires BMI 30 with a comorbid condition (like hypertension or sleep apnea) or BMI 35 without comorbidities, plus documented diet and exercise failure