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A study from the University of Pennsylvania and Cedars-Sinai Medical Center found a 700% increase in use of the drugs for patients without diabetes from 2019 to 2023

Pfizer terminated lotiglipron in October 2023 due to dose-dependent liver enzyme elevations, and subsequently discontinued danuglipron in April 2025 after a single case of potential drug-induced liver injury was identified in a dose-optimization study

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Allulose is known as a non-chemical sugar alternative

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Dr