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Methods A pooled post hoc analysis of 11 randomized clinical trials (N = 4595) of 1030 weeks duration from the exenatide once-weekly (QW) development program evaluated heart rate with exenatide QW (intervention group) and exenatide twice daily (BID), liraglutide, and non-GLP-1RAs (insulin, metformin, pioglitazone, and sitagliptin) (comparison groups)

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Keep in mind that because semaglutides trigger the release of insulin, which converts sugar from food into blood glucose, if youre not eating enough, you could then be at risk of low blood sugar

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Constipation affects up to 25% of GLP-1 users during weight loss therapy