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The body has the raw material it needs to protect and maintain lean tissue

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[DOI] [PubMed] [Google Scholar] 154.Sacks F.M., Bray G.A., Carey V.J., Smith S.R., Ryan D.H., Anton S.D., McManus K., Champagne C.M., Bishop L.M., Laranjo N., et al

One study showed the metformin-treated group showed 3.8kg of weight loss compared to sulfonylurea-treated group in 6 months

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However, weight loss typically occurs more rapidly in the early stages and then may plateau or even slightly increase despite maintaining a calorie deficit