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Contraindications and Patient Selection Safe prescribing of these agents requires thorough contraindication screening

doi:10.1038/s41591-023-02669-x Nunn E, Jaiswal N, Gavin M, et al

Wegovy Worsens Stomach Paralysis Symptoms An August 2020 study named titled Diabetic Gastroparesis: A Review cautioned that drugs like Wegovy, Ozempic, and other GLP-1 diabetes medications could exacerbate stomach paralysis

Wegovy and Ozempic proved that pharmacological weight loss could actually work at scale, with patients dropping 15% of their body weight on a weekly injection

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These discrepancies may reflect species-specific differences that include the relative accessibility and importance of GLP-1R circuits in the CNS compared with those in the peripheral nervous system for controlling appetite, or these discrepancies may be due to other limitations, including the dose, potency, pharmacokinetics, and selectivity of the antagonist used and the short-term observation period