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Conclusion GLP-1, the next PD-1

The glucagon receptor component adds metabolic effects beyond appetite suppression, including enhanced fat oxidation and energy expenditure

These include potential benefits in obesity management and even cardiovascular disease prevention in non-diabetic patients

Many individuals prescribed these medications may have pre-existing risk factors for reflux, including obesity itself, which is a well-established independent risk factor for GORD

These potential cardioprotective effects may be related to the favourable actions of metformin on lipid metabolism, vascular smooth muscle, hypercoagulation, platelet hyperactivity, cardiomyocyte intracellular calcium handling and endothelial function [24]

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