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2022;6:e42191
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Short-term semaglutide treatment improves FGF21 responsiveness in primary hepatocytes isolated from high fat diet challenged mice

Based on this observation, DPP-4 inhibitors may be less effective in high-fat-diet-fed Gcg RA Null and Gcg RA VilCre mice that depend on GIP to mediate DPP-4 inhibitory effects
Whereas fMRI does not allow inferences on neurotransmission, these results are well in line with work in animals (Decarie-Spain & Kanoski, 2021