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Description
The failure of this high leptin (and therapy with exogenous leptin) in the obese state to decrease feeding and return adipose mass to normal has suggested the existence of leptin resistance, in which obesity impairs leptin action Obesity provokes a number of changes to hypothalamic anatomy and physiology, many of which have been invoked as potential mediators of leptin resistance
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Archives of Neurology, 69 (11), 1420-1429

Urogenital: Impaired urination
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