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Pivotal Phase 2 Trial Results The pivotal Phase 2 trial, published by Jastreboff and colleagues in the New England Journal of Medicine in August 2023, enrolled 338 adults with obesity (BMI 30) or overweight (BMI 27) with at least one weight-related comorbidity but without diabetes

Side Effects: Both medications have similar side effects, such as nausea and diarrhea, but individual responses can vary

Studies have reported: modest increases in total testosterone levels improvements in sexual function scores better metabolic markers alongside hormonal gains These improvements appear closely tied to weight loss and metabolic recovery

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Clinical observations, while valuable, lack the controls necessary for confident conclusions

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