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Semaglutide is FDA-approved for obesity at BMI 30+, but doctors may prescribe it off-label for lower BMIs when other health factors apply

Ozempic is primarily prescribed for managing type 2 diabetes, while Wegovy is approved for weight management in people with obesity or overweight conditions

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Eligibility criteria for selecting studies Eligible randomised controlled trials enrolled adults with type 2 diabetes who received GLP-1RA treatments and compared effects with placebo or any GLP-1RA drug, with a follow-up duration of at least 12 weeks

Front Endocrinol (Lausanne)