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Description
As clinical trials progress and regulatory approvals are sought, these therapies have the potential to redefine obesity management and improve patient outcomes worldwide
New England Journal of Medicine, 388(3), 251263
In terms of study subjects, the focus was on patients with T2DM, T2DM patients complicated with cardiovascular diseases, or animal models of diabetes-related heart diseases
In a subsequent prospective cohort, liraglutide not only improved metabolic parameters but also demonstrated immunomodulatory effects, with a significant reduction in circulating T-cell populations, particularly T cells, which are known to play a key role in PsO pathogenesis by producing IL17 and IL22 (26)
Its chemical formula is based on the GIP amino acid sequence and its half-life of approximately 5 days is compatible with a once-weekly subcutaneous administration
doi: 10.1186/s12933-015-0177-4 68 ZhangYZhouHWuWShiCHuSYinTet al
