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Cardiomyocyte/cardiac fibroblast dysfunction is related to abnormal proliferation, apoptosis, hypertrophy, as well as inflammation and fibrosis, which may be caused by mitochondrial dysfunction and metabolic disorders

It adds to other variables recently suggested to affect the interaction of GLP-1R agonists with depression, which include existing and treated diabetes or obesity, age, duration of treatment, whether comparisons are made to control groups receiving placebo or other antiobesity medications, and whether patients with preexisting psychiatric diagnosis are included

GLP-1s, in any dosage, can interact with other medications, such as blood thinners and hormonal birth control

Landgraf, D

Very recently, Ravussin et al

D., Isidro-Llobet, A., Parker, J