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The answer is yes: clinical trials show semaglutide produces meaningful weight loss across the spectrum, with average reductions ranging from 5% to 15% of body weight depending on dose and adherence

J Endocrinol 2007

The generally accepted maximum dose for weight loss is 2.4 mg per week

The oral Wegovy pill offers an identical formulation in daily tablet form, ideal for patients who would prefer non-injection treatments

These areas of study make it a valuable tool for investigating metabolic function, energy balance, and glucose homeostasis

Dulaglutide did not work in an RCT for smoking cessation in mostly obese adults, but alcohol consumption decreased in the treatment group (Lengsfeld S et al, eClinicalMedicine 2023;57:101865