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Over 18 months, the condition occurred in approximately 8 cases per 10,000 GLP-1 users, compared with 4 to 6 cases among comparison groups

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While newly approved pharmacotherapies such as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) show efficacy, their clinical utility remains constrained by dose-dependent gastrointestinal complications, underscoring the urgent need for safer alternatives

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GLP-1 and similar hormone-activating medications can significantly reduce appetite, support weight loss and control blood sugar

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