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A: Semaglutide is a glucagon-like peptide-1 (GLP-1) agonist

Retatrutide is Eli Lillys once weekly injectable that targets three pathways at the same time, GLP-1, GIP, and glucagon

Adults aged 18 years (20 years in Taiwan) with a diagnosis of type 2 diabetes, HbA1c between 53 and 91 mmol/mol (inclusive) and treated with a stable daily dose of metformin were eligible for inclusion

The science, promise and clinical development of GLP-1 and GIP receptor agonists in obesity

Strengths Broad metabolic effects (insulin, lipid, inflammation) Some supportive human clinical data Potential synergy with conventional treatments Limitations Effects on GLP-1 are indirect or inferred May cause insomnia, nervousness, or interact with other medications Response variability among individuals Gymnema Best for: Someone with mild to moderate type 2 diabetes seeking adjunct botanical support, particularly when wanting support of pancreatic and gut hormone health
